Repository: Freie Universität Berlin, Math Department

A new approach for biomarker detection using fusion networks

Rams, Mona (2016) A new approach for biomarker detection using fusion networks. Masters thesis, Freie Universität Berlin.

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Abstract

In this thesis we propose a new approach for biomarker detection using single source and fusion networks. Our algorithm detects metastable regions with similar and high weights in networks. Standard methods for biomarker detection analyse the differentially expression, or other biological measurement, of genes, without taking any further biological knowledge into account. Network approaches include further insight into the analysis, nevertheless most of them are limited to the examination of one data type. With our fusion network algorithm we introduce a new and promising approach. We analyse breast cancer gene expression and methylation data using our fusion network approach. The proposed method detects known and novel biomarkers, which are highly supported by breast cancer literature, biological pathways, and classification power.

Item Type:Thesis (Masters)
Subjects:Mathematical and Computer Sciences
Divisions:Department of Mathematics and Computer Science > Institute of Mathematics > Comp. Proteomics Group
Department of Mathematics and Computer Science > Institute of Mathematics
ID Code:1986
Deposited By: Admin Administrator
Deposited On:27 Nov 2016 23:06
Last Modified:03 Mar 2017 14:42

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