Schütte, Ch. and Sarich, M.
(2015)
*A critical appraisal of Markov state models.*
The European Physical Journal Special Topics, 224
(12).
pp. 2445-2462.
ISSN 1951-6355

Full text not available from this repository.

Official URL: http://link.springer.com/article/10.1140%2Fepjst%2...

## Abstract

Markov State Modelling as a concept for a coarse grained description of the essential kinetics of a molecular system in equilibrium has gained a lot of attention recently. The last 10 years have seen an ever increasing publication activity on how to construct Markov State Models (MSMs) for very different molecular systems ranging from peptides to proteins, from RNA to DNA, and via molecular sensors to molecular aggregation. Simultaneously the accompanying theory behind MSM building and approximation quality has been developed well beyond the concepts and ideas used in practical applications. This article reviews the main theoretical results, provides links to crucial new developments, outlines the full power of MSM building today, and discusses the essential limitations still to overcome.

Item Type: | Article |
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Subjects: | Mathematical and Computer Sciences |

Divisions: | Department of Mathematics and Computer Science > Institute of Mathematics Department of Mathematics and Computer Science > Institute of Mathematics > BioComputing Group |

ID Code: | 1733 |

Deposited By: | BioComp Admin |

Deposited On: | 21 Sep 2015 10:26 |

Last Modified: | 22 Oct 2015 12:57 |

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