Nowatzky, Yannek and Russo, Francesco and Lisec, Jan and Kister, Alexander and Reinert, Knut and Muth, Thilo and Benner, Philipp (2025) FIORA: Local neighborhood-based prediction of compound mass spectra from single fragmentation events. Nature Communications, 16 (1).
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Official URL: https://www.nature.com/articles/s41467-025-57422-4
Abstract
Non-targeted metabolomics holds great promise for advancing precision medicine and biomarker discovery. However, identifying compounds from tandem mass spectra remains a challenging task due to the incomplete nature of spectral reference libraries. Augmenting these libraries with simulated mass spectra can provide the necessary references to resolve unmatched spectra, but generating high-quality data is difficult. In this study, we present FIORA, an open-source graph neural network designed to simulate tandem mass spectra. Our main contribution lies in utilizing the molecular neighborhood of bonds to learn breaking patterns and derive fragment ion probabilities. FIORA not only surpasses state-of-the-art fragmentation algorithms, ICEBERG and CFM-ID, in prediction quality, but also facilitates the prediction of additional features, such as retention time and collision cross section. Utilizing GPU acceleration, FIORA enables rapid validation of putative compound annotations and large-scale expansion of spectral reference libraries with high-quality predictions.
Item Type: | Article |
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Subjects: | Mathematical and Computer Sciences > Computer Science |
Divisions: | Department of Mathematics and Computer Science > Institute of Computer Science > Algorithmic Bioinformatics Group |
ID Code: | 3246 |
Deposited By: | Anja Kasseckert |
Deposited On: | 29 Jan 2025 15:47 |
Last Modified: | 15 Sep 2025 14:43 |
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