Repository: Freie Universität Berlin, Math Department

Lithium influences whole‐organism metabolic rate in Drosophila subobscura

Kurbalija Novičić, Zorana and Bodén, Robert and Kozarski, Ksenija and Jelić, Mihailo and Jovanović, Vladimir M. and Cunningham, Janet L. (2021) Lithium influences whole‐organism metabolic rate in Drosophila subobscura. Journal of Neuroscience Research, 99 (1). pp. 407-418. ISSN 0360-4012

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Lithium is widely used to treat bipolar disorder. However, the efficacy and vulnerability as to its side effects are known to differ. Although the specific biochemical mechanism of action is still elusive, lithium may influence mitochondrial function, and consequently, metabolism. Lithium exposure in this study was conducted on a unique set of mito-nuclear introgression lines of Drosophila subobscura to disentangle the independent effects of mitochondrial DNA (mtDNA) against a common nuclear DNA background. The study addressed three issues: (a) whether lithium has a dose-dependent effect on whole-organism metabolic rate, (b) whether mtDNA haplotypes show divergent metabolic efficiency measured by metabolic rate to lithium exposure and (c) whether lithium influences the whole-organism metabolic rate across sexes. The results confirm that lithium influenced the whole-organism metabolic rate, showing a subtle balance between efficacy and adverse effects within a narrow dose range. In addition, lithium exposure was found to influence metabolism differently based on mtDNA haplotypes and sex. This preliminary research may have a range of biological implications for the role of mitochondrial variability in psychiatric disease and treatment by contributing to the understanding and predicting of the lithium treatment response and risk for toxic side effects.

Item Type:Article
Subjects:Mathematical and Computer Sciences > Computer Science
Divisions:Department of Mathematics and Computer Science > Institute of Computer Science
ID Code:2728
Deposited By: Anja Kasseckert
Deposited On:15 Feb 2022 16:42
Last Modified:15 Feb 2022 16:42

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