Repository: Freie Universit├Ąt Berlin, Math Department

Software Supported Modelling in Pharmacokinetics

Telgmann, R. and von Kleist, M. and Huisinga, W. (2006) Software Supported Modelling in Pharmacokinetics. In: Computational Life Sciences II.

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution Non-commercial.

1MB

Official URL: http://dx.doi.org/10.1007/11875741_21

Abstract

A powerful new software concept to physiologically based pharmacokinetic (PBPK) modelling of drug disposition is presented. It links the inherent modular understanding in pharmacology with orthogonal design principles from software engineering. This concept allows for flexible and user-friendly design of pharmacokinetic whole body models, data analysis, hypotheses testing or extrapolation. The typical structure of physiologically-based pharmacokinetic models is introduced. The resulting requirements from a modelling and software engineering point of view and its realizations in the software tool MEDICI-PK [9] are described. Finally, an example in the context of drug-drug interaction studies is given that demonstrates the advantage of defining a whole-body pharmacokinetic model in terms of the underlying physiological processes quite impressively: A system of 162 ODEs is automatically compiled based on the specification of 7 local physiological processes only.

Item Type:Conference or Workshop Item (UNSPECIFIED)
Subjects:Mathematical and Computer Sciences > Mathematics
Divisions:Department of Mathematics and Computer Science > Institute of Mathematics
Department of Mathematics and Computer Science > Institute of Mathematics > BioComputing Group
ID Code:122
Deposited By: Admin Administrator
Deposited On:03 Jan 2009 20:20
Last Modified:03 Mar 2017 14:40

Repository Staff Only: item control page